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Merck (MRK) explained: how it makes money, how it's doing, what protects it

A plain-English guide to the company behind the cancer medicine Keytruda. See what it sells, where the money goes, who it competes with and what protects it.

⚡What does Merck do, in 30 seconds?

Merck invents, makes and sells medicines and vaccines for people, and medicines and vaccines for animals 1. It sold $65.0bn ✓ in FY2025. Its cancer medicine Keytruda made up 49% of total 2025 sales 45.

Revenue, FY2025
$65.0bn✓
Profit, FY2025
$18.3bn✓
Sales growth, 4 quarters to 30 Jun 2026
4.6%✓
Net cash (cash and investments minus borrowings; leases and stakes in other companies not counted), 30 Jun 2026
-$45.5bn✓
Headquarters
Rahway, New Jersey 133
Known abroad as
MSD, outside the US and Canada 19
Employees
About 75,000 at 31 December 2025 23
Research staff
About 24,700 at 31 December 2025 22
CEO
Robert M. Davis, CEO since July 2021 and chairman since December 2022 30
Fiscal year ends
31 December 1

📱What does Merck sell?

Merck reports two segments, and medicines and vaccines for people bring in most of its sales, 89% ✓ in FY2025. Here is what each part is and who buys from it.

💉

Pharmaceuticals

Medicines and vaccines for people 1. This segment brought in $58.1bn ✓ in FY2025. The biggest product is Keytruda, a cancer immunotherapy approved for many cancers, including lung cancer and melanoma 3. Keytruda and Keytruda Qlex, a version given as a shot under the skin, sold $31,680 million in 2025 4536. Gardasil vaccines, which help prevent certain cancers and other diseases caused by HPV, sold $5,233 million in 2025 43. Winrevair, for adults with pulmonary arterial hypertension, sold $1,443 million in 2025 43. Other medicines include Januvia and Janumet for type 2 diabetes 43. Merck also books alliance revenue, its share of profits, from Lynparza with AstraZeneca and Lenvima with Eisai 47. Merck also sells vaccines against measles, mumps, rubella, chickenpox and pneumococcal disease 3.

👥 Drug wholesalers and retailers, hospitals, government agencies and drug-benefit managers buy the medicines 1. Doctors, wholesalers, distributors and governments buy the vaccines 1.

🐄

Animal health

Medicines, vaccines and health products for farm animals and pets, plus digital products that identify and monitor animals 1. This segment brought in $6.4bn ✓ in FY2025. Products for farm animals sold $3,896 million in 2025, and products for pets $2,458 million 4. A well-known pet brand is Bravecto, for fleas and ticks on dogs and cats; the original products last up to 12 weeks 3.

👥 Vets, distributors, farmers, animal producers and pet owners 1.

🧾

Other

Revenue outside the two segments came to $0.5bn ✓ in FY2025, or about 1% ✓ of the total.

👥 A small amount of revenue that Merck does not assign to either segment.

How the mix has shifted

Revenue mix by productFY2023Pharmaceuticals: $53.6bn (89%)Pharmaceuticals 89%Animal health: $5.6bn (9%)Animal health 9%Other: $0.9bn (2%)FY2024Pharmaceuticals: $57.4bn (89%)Pharmaceuticals 89%Animal health: $5.9bn (9%)Animal health 9%Other: $0.9bn (1%)FY2025Pharmaceuticals: $58.1bn (89%)Pharmaceuticals 89%Animal health: $6.4bn (10%)Animal health 10%Other: $0.5bn (1%)
Revenue mix by productFY23Pharmaceuticals: $53.6bn (89%)89%Animal health: $5.6bn (9%)Other: $0.9bn (2%)FY24Pharmaceuticals: $57.4bn (89%)89%Animal health: $5.9bn (9%)Other: $0.9bn (1%)FY25Pharmaceuticals: $58.1bn (89%)89%Animal health: $6.4bn (10%)Other: $0.5bn (1%)PharmaceuticalsAnimal healthOther
Share of revenue by business line, by fiscal year. Source: Merck & Co., Inc. 10-K filed 2026-02-24.

Where the customers are

The United States brought in 56% ✓ of Merck's sales in FY2025, or $36.4bn ✓. Europe, the Middle East and Africa added 22% ✓. Latin America added 5% ✓, the rest of Asia Pacific 5% ✓, Japan 4% ✓ and China 3% ✓. Sales by Merck's businesses outside the US fell to 44% of the total in 2025, from 53% in 2023 34. Merck's business in China shrank a lot in 2025, with lower Gardasil sales 215.

Revenue by regionUnited States$36.4bn 56% of salesEurope, Middle East and Africa$14.6bn 22% of salesLatin America$3.4bn 5% of salesAsia Pacific (other than Japan and China)$3.0bn 5% of salesJapan$2.7bn 4% of salesChina$1.9bn 3% of salesOther$2.9bn 4% of sales
Revenue by regionUnited States$36.4bn 56%Europe, Middle East and Africa$14.6bn 22%Latin America$3.4bn 5%Asia Pacific (other than Japan and China)$3.0bn 5%Japan$2.7bn 4%China$1.9bn 3%Other$2.9bn 4%
Revenue by region, FY2025. Source: Merck & Co., Inc. 10-K filed 2026-02-24.

💸How does Merck make money?

Follow the money: what customers pay for, what it costs to make, and what is left as profit.

Money map FY2025: how revenue turns into profitPharmaceuticals → Revenue: $58.1bnAnimal health → Revenue: $6.4bnOther → Revenue: $0.5bnRevenue → Gross profit: $48.6bnRevenue → Cost of sales: $16.4bnGross profit → Operating profit: $22.1bnOther operating income → Operating profit: $0.1bnGross profit → R&D: $15.8bnGross profit → Selling & admin: $10.7bnOperating profit → Net income: $18.3bnOperating profit → Income tax: $2.8bnOperating profit → Other costs: $1.2bnPharmaceuticals$58.1bn · 89%Animal health$6.4bn · 10%Other$0.5bn · 1%Revenue$65.0bnGross profit$48.6bn · 75%Cost of sales$16.4bn · 25%Other operating income$0.1bn · <1%Operating profit$22.2bn · 34%R&D$15.8bn · 24%Selling & admin$10.7bn · 17%Net income$18.3bn · 28%Income tax$2.8bn · 4%Other costs$1.2bn · 2%
Money map FY2025: how revenue turns into profitPharmaceuticals: $58.1bnAnimal health: $6.4bnOther: $0.5bnPharmaceuticals$58.1bn · 89%Animal health$6.4bn · 10%Other$0.5bn · 1%Revenue: $65.0bnRevenue$65.0bn · 100%Gross profit: $48.6bnCost of sales: $16.4bnGross profit$48.6bn · 75%Cost of sales$16.4bn · 25%Operating profit: $22.2bnR&D: $15.8bnSelling & admin: $10.7bnOperating profit$22.2bn · 34%R&D$15.8bn · 24%Selling & admin$10.7bn · 17%Net income: $18.3bnIncome tax: $2.8bnOther costs: $1.2bnNet income$18.3bn · 28%Income tax$2.8bn · 4%Other costs$1.2bn · 2%
Money map (a Sankey diagram): band widths are to scale. Hover a band for the amount. Source: Merck & Co., Inc. 10-K filings.

Merck sold $65.0bn ✓ of medicines and vaccines in FY2025. Making them cost $16.4bn ✓. What is left is gross profit, the money kept after paying for what was sold. That came to $48.6bn ✓.

Next come the costs of running the company. Research and development, the search for new medicines, took $15.8bn ✓. Sales, marketing and admin took $10.7bn ✓. Other operating items came to -$0.1bn ✓, a small net gain. That left operating profit, the profit from the main business, of $22.2bn ✓. Interest and other items came to -$1.2bn ✓, and tax took $2.8bn ✓. Net income was $18.3bn ✓. Put simply, out of every hundred dollars of sales, Merck spent about $24 ✓ on research and kept about $28 ✓ as profit.

Out of every $100 customers paid in FY2025…

Making the products and services $25Research and development $24Selling and admin $17Other costs (interest and losses) $2Income tax $4Profit kept $28
💡
Medicines and vaccines for people made up 89% ✓ of Merck's FY2025 sales, and animal health 10% ✓. One medicine stands out: Keytruda made up 49% of Merck's total 2025 sales 45.

⏱️ Merck by the clock

Spread the FY2025 totals evenly over its 365 days and you get this. Source: Merck & Co., Inc. 10-K [8].

🛒
$178m
in sales every day
⏱️
$579
of profit every second
🔬
$43m
on research every day
🎁
$36m
handed to shareholders every day

📈How is Merck doing?

Merck kept growing in FY2025, but slowly. Sales reached $65.0bn ✓, up 1.3% ✓ on FY2024. Operating margin was 34.2% ✓, so about a third of sales became operating profit. Two big products moved in opposite directions. Keytruda and Keytruda Qlex sales rose to $31,680 million in 2025, from $29,482 million 45. Gardasil and Gardasil 9 sales fell to $5,233 million, from $8,583 million 43.

Profit swings a lot from year to year. In FY2023, research and development costs reached $30.5bn ✓, leaving operating profit of just $3.1bn ✓. In the four quarters to 30 June 2026, sales were $66.6bn ✓, up 4.6% ✓ on the four quarters before.

In the third quarter of 2026, which ended on 30 September, Merck's sales were $18,085 million, up 5% on a year earlier 20. Keytruda and Keytruda Qlex sold $8,601 million in that quarter, up 6% 20. Winrevair sales rose 93% to $694 million 20. Januvia and Janumet sales fell 39%, after generic copies arrived in the US 20. As of 29 October 2026, Merck expected 2026 sales of $66.8 billion to $67.3 billion 26.

Over a longer stretch, growth has been faster. From FY2019 to FY2025, sales grew 8.8% ✓ a year on average, from $39.1bn ✓. Sales rose in each of the 6 ✓ years after FY2019. Gross margin rose from 69.3% ✓ to 74.8% ✓.

📝 The report card

Merck earns a top mark for cash, a good mark for profit, a middle mark for steadiness, a low mark for growth and a fail for its balance sheet. Every company is graded on the same fixed scale, so an A means the same thing on every page. The strip shows where Merck (orange) and its 4 peers land; further right is better.

D

Growth

Sales growth per year, last 3 fiscal years
3.1% · peer median 3.7%
#3 of 5 in the peer group
A ≥ 15.0%B ≥ 10.0%C ≥ 5.0%D ≥ 0.0%F below 0.0%

Merck's sales grew 3.1% ✓ a year over its last three fiscal years, which earns a D ✓. Eli Lilly grew 31.7% ✓ a year, an A ✓, while Pfizer's sales growth was -14.8% ✓ a year, an F ✓.

Why this measure? (higher is better)

Growing sales is the engine of a business. Mature giants rarely grow fast, so 5% a year already earns a C.

B

Profitability

Operating margin, last 3 years combined
24.4% · peer median 23.3%
#3 of 5 in the peer group
A ≥ 30.0%B ≥ 20.0%C ≥ 10.0%D ≥ 5.0%F below 5.0%

Over the last three years combined, Merck kept 24.4% ✓ of sales as operating profit, a B ✓. The weak FY2023, with an operating margin of 5.2% ✓, pulls that figure down. Eli Lilly kept 31.6% ✓, enough for an A ✓.

Why this measure? (higher is better)

Operating margin is the share of each sales dollar left after running the business. Software and platforms often clear 30%; hardware makers usually sit below 10%.

A

Cash generation

Free cash flow as a share of sales, last 3 years combined
20.9% · peer median 17.2%
#3 of 5 in the peer group
A ≥ 20.0%B ≥ 15.0%C ≥ 10.0%D ≥ 5.0%F below 5.0%

Over the last three years combined, Merck turned 20.9% ✓ of sales into free cash flow, just above the 20% line for an A ✓. AbbVie did better at 33.6% ✓, while Eli Lilly managed 9.4% ✓.

Why this measure? (higher is better)

Free cash flow is the cash left after paying for factories, data centres and equipment. It funds dividends, buybacks and new bets.

F

Balance sheet

Net cash (cash and investments minus borrowings; leases and stakes in other companies not counted) as a share of a year's sales
-52.0% · peer median -70.5%
#2 of 5 in the peer group
A ≥ 20.0%B ≥ 5.0%C ≥ -10.0%D ≥ -30.0%F below -30.0%

Merck's borrowings were larger than its cash and investments. At the end of FY2025, its net cash (cash and investments minus borrowings; leases and stakes in other companies not counted) was -52.0% ✓ of a year's sales, an F ✓. AbbVie is lower still at -91.9% ✓, also an F ✓.

Why this measure? (higher is better)

More cash than debt gives a company room to ride out bad years. Some debt is normal; a lot of it makes a company fragile.

C

Steadiness

How much yearly sales growth swings (standard deviation, up to 10 years)
8.5% · peer median 13.7%
#2 of 5 in the peer group
A ≤ 5.0%B ≤ 8.0%C ≤ 12.0%D ≤ 18.0%F above 18.0%

Merck's yearly growth rates swing a fair amount, with a standard deviation of 8.5% ✓, just above the 8% line for a B, so it earns a C ✓. Growth ranged from 1.3% ✓ in FY2025 to 21.7% ✓ in FY2022. Johnson & Johnson is steadier at 2.2% ✓, an A ✓, and Pfizer far less steady at 41.5% ✓.

Why this measure? (lower is better)

Steady growers are easier to plan around. Big swings mean sales depend on product cycles, the economy or one-off events.

🧑‍🏫 How the grades work
  1. Same scale for everyone. Each measure has fixed cut-offs (shown under each strip). Clear the A line and you get an A, whatever your peers do.
  2. Three years together. Profitability and cash generation add up the last three fiscal years before dividing, so one unusual year counts for less than it would on its own (a year much bigger than the others still weighs most).
  3. Peers for context. The rank shows how Merck compares with the group. Companies within 0.1 percentage point share a rank.
  4. Same source. Every company's figures come from its own latest annual report (10-K), so fiscal years end in different months.
  5. Judgement, openly stated. The cut-offs are QuantVantage.ai's view of what good looks like for a large, established company. They are not a forecast or a recommendation.

7 years at a glance

Revenue
$65.0bn
FY2025
Revenue by fiscal yearFY2019: $39.1bnFY2020: $41.5bnFY2021: $48.7bnFY2022: $59.3bnFY2023: $60.1bnFY2024: $64.2bnFY2025: $65.0bnFY2019FY2025
Operating margin
34.2%
FY2025
Operating marginFY2019FY2025
Free cash flow
$12.4bn
FY2025
Free cash flow by fiscal yearFY2019: $10.1bnFY2020: $5.8bnFY2021: $8.7bnFY2022: $14.7bnFY2023: $9.1bnFY2024: $18.1bnFY2025: $12.4bnFY2019FY2025
Net cash
-$33.8bn
end of FY2025
Net cash by fiscal yearFY2019: -$14.4bnFY2020: -$23.0bnFY2021: -$24.6bnFY2022: -$16.5bnFY2023: -$27.7bnFY2024: -$23.0bnFY2025: -$33.8bnFY2019FY2025

Where the cash goes

Over the seven fiscal years from FY2019 to FY2025, Merck handed back less cash than its free cash flow. It spent $63.6bn ✓ on buybacks and dividends, against $78.9bn ✓ of free cash flow. In FY2025, free cash flow fell to $12.4bn ✓, from $18.1bn ✓ in FY2024. Payouts that year were 107% ✓ of free cash flow: $8.2bn ✓ of dividends and $5.1bn ✓ of buybacks.

Free cash flow vs cash returned to shareholders$0bn$10bnFY2019 free cash flow $10.1bnFY2019 buybacks + dividends $10.5bnFY19FY2020 free cash flow $5.8bnFY2020 buybacks + dividends $7.5bnFY20FY2021 free cash flow $8.7bnFY2021 buybacks + dividends $7.5bnFY21FY2022 free cash flow $14.7bnFY2022 buybacks + dividends $7.0bnFY22FY2023 free cash flow $9.1bnFY2023 buybacks + dividends $8.8bnFY23FY2024 free cash flow $18.1bnFY2024 buybacks + dividends $9.1bnFY24FY2025 free cash flow $12.4bnFY2025 buybacks + dividends $13.3bnFY25
Free cash flow vs cash returned to shareholders$0bn$10bnFY2020 free cash flow $5.8bnFY2020 buybacks + dividends $7.5bnFY20FY2021 free cash flow $8.7bnFY2021 buybacks + dividends $7.5bnFY21FY2022 free cash flow $14.7bnFY2022 buybacks + dividends $7.0bnFY22FY2023 free cash flow $9.1bnFY2023 buybacks + dividends $8.8bnFY23FY2024 free cash flow $18.1bnFY2024 buybacks + dividends $9.1bnFY24FY2025 free cash flow $12.4bnFY2025 buybacks + dividends $13.3bnFY25
■ Free cash flow   ■ Buybacks + dividends. Source: Merck & Co., Inc. 10-K filings.

🧮Ratios 101: what are Merck's key financial ratios?

Ratios shrink Merck's big numbers into easy comparisons with other drug makers, and they show how much it spends on research. A ratio divides one number by another so companies of any size can be compared. Each card shows the formula with Merck's real FY2025 numbers, the peer median and the trend.

💰 Profitability: how much of each sale is kept?

Higher is better

Gross margin

74.8%
Gross profit$48.6bn$65.0bnSales=74.8%

What is left from each sale after paying to make the product or deliver the service.

👉 Merck kept 74.8% ✓ of FY2025 sales after the cost of making its products, up from 67.2% ✓ in FY2020 and a little above the 72.3% ✓ peer median.

📏 Rule of thumb: Above 40% usually signals pricing power or a big software or services mix.

Peer median 72.3% (4 peers)FY2020 67.2%
Gross margin by fiscal yearFY2019FY2025
Higher is better

Operating margin

34.2%
Operating profit$22.2bn$65.0bnSales=34.2%

What is left after also paying for research, marketing and running the company.

👉 At 34.2% ✓ in FY2025, Merck's operating margin beats the 26.5% ✓ peer median and its own 13.8% ✓ of FY2020.

📏 Rule of thumb: Above 20% is strong for a large company.

Peer median 26.5% (4 peers)FY2020 13.8%
Operating margin by fiscal yearFY2019FY2025
Higher is better

Net margin

28.1%
Net income$18.3bn$65.0bnSales=28.1%

The bottom line: profit after interest and taxes, per dollar of sales.

👉 Merck kept 28.1% ✓ of FY2025 sales as final profit, above the 20.4% ✓ peer median.

📏 Rule of thumb: Above 15% is strong; one-off tax items can move it in a single year.

Peer median 20.4% (4 peers)FY2020 17.0%
Net margin by fiscal yearFY2019FY2025
It depends

Return on equity (ROE)

34.7%
Net income$18.3bn$52.6bnShareholders' equity=34.7%

Profit earned for each dollar that shareholders have left in the company.

👉 ROE of 34.7% ✓ in FY2025 is a little above the 32.9% ✓ median of the peers it can be worked out for.

📏 Rule of thumb: Around 15% or more is good, but buybacks shrink equity and can make ROE look huge.

Peer median 32.9% (3 peers)FY2020 27.9%
Return on equity (ROE) by fiscal yearFY2019FY2025

⚙️ Efficiency: how hard do the assets work?

Higher is better

Return on assets (ROA)

13.3%
Net income$18.3bn$136.9bnTotal assets=13.3%

Profit earned from everything the company owns, however it was paid for.

👉 Merck earned 13.3% ✓ on everything it owned in FY2025, above the 8.6% ✓ peer median.

📏 Rule of thumb: Above 10% is strong; banks and factories usually earn less.

Peer median 8.6% (4 peers)FY2020 7.7%
Return on assets (ROA) by fiscal yearFY2019FY2025
Higher is better

Asset turnover

0.5x
Sales$65.0bn$136.9bnTotal assets=0.5x

Dollars of sales squeezed out of each dollar of assets.

👉 Merck's FY2025 sales were 0.5x ✓ the value of everything it owned, the same as the 0.5x ✓ peer median.

📏 Rule of thumb: Retailers often top 2x; asset-heavy businesses can sit below 0.5x.

Peer median 0.5x (4 peers)FY2020 0.5x
Asset turnover by fiscal yearFY2019FY2025
Lower is better

Inventory days

148 days
Inventory$6.7bn$16.4bnCost of sales× 365=148 days

How many days of products sit in warehouses before they are sold.

👉 Merck held 148 ✓ days of stock at the end of FY2025, below the peer median of 207 ✓ days.

📏 Rule of thumb: Fewer days means less cash tied up and less risk of products going stale.

Peer median 207 days (4 peers)FY2020 149 days
Inventory days by fiscal yearFY2019FY2025

🛟 Safety: could it survive a bad year?

It depends

Current ratio

1.5x
Current assets$43.5bn$28.3bnCurrent liabilities=1.5x

Can short-term assets (cash, money owed by customers, stock) pay the bills due within a year?

👉 Merck's 1.5x ✓ means that at the end of FY2025 it had $43.5bn ✓ of short-term assets against $28.3bn ✓ of bills due within a year. That is above the 1.1x ✓ peer median.

📏 Rule of thumb: Above 1.0x is the classic comfort line, but cash-rich giants can run below it on purpose.

Peer median 1.1x (4 peers)FY2020 1.0x
Current ratio by fiscal yearFY2019FY2025
Lower is better

Debt to equity

0.9x
Total debt$49.3bn$52.6bnShareholders' equity=0.9x

How much the company has borrowed for each dollar shareholders have in it.

👉 At the end of FY2025, Merck's total debt was 0.9x ✓ its shareholders' equity, down from 1.3x ✓ in FY2020. That is above the 0.7x ✓ median of the peers it can be worked out for.

📏 Rule of thumb: Below 1.0x is conservative. Like ROE, it can rise when buybacks shrink equity, even if debt has not changed.

Peer median 0.7x (3 peers)FY2020 1.3x
Debt to equity by fiscal yearFY2019FY2025
Higher is better

Interest cover

16.4x
Operating profit$22.2bn$1.4bnInterest expense=16.4x

How many times over operating profit could pay the year's interest bill.

👉 In FY2025, operating profit covered interest costs 16.4x ✓, close to the 16.1x ✓ peer median and up from 6.9x ✓ in FY2020.

📏 Rule of thumb: Above 5x is comfortable; below 2x is a warning sign.

Peer median 16.1x (4 peers)FY2020 6.9x
Interest cover by fiscal yearFY2019FY2025

💵 Cash and owners: where does the money end up?

Higher is better

Cash conversion

0.7x
Free cash flow$12.4bn$18.3bnNet income=0.7x

Does reported profit turn into real cash? Free cash flow is operating cash minus capital spending.

👉 Merck turned profit into free cash at 0.7x ✓ in FY2025, below the 1.0x ✓ peer median.

📏 Rule of thumb: Near or above 1.0x means profits are backed by cash.

Peer median 1.0x (4 peers)FY2020 0.8x
Cash conversion by fiscal yearFY2019FY2025
It depends

R&D intensity

24.3%
R&D$15.8bn$65.0bnSales=24.3%

How much of each sales dollar goes into inventing future products.

👉 Merck spent 24.3% ✓ of FY2025 sales on research, well above the 16.1% ✓ peer median but down from 32.3% ✓ in FY2020.

📏 Rule of thumb: Tech companies often spend 10% to 20%; more is not always better if it does not pay off.

Peer median 16.1% (4 peers)FY2020 32.3%
R&D intensity by fiscal yearFY2019FY2025
Lower is better

Stock pay

1.3%
Share-based pay$0.8bn$65.0bnSales=1.3%

Pay given to staff in shares instead of cash. It is a real cost to owners because it adds shares.

👉 Stock pay was 1.3% ✓ of FY2025 sales, close to the 1.4% ✓ peer median and up from 1.1% ✓ in FY2020.

📏 Rule of thumb: Under 5% of sales is modest for a tech company.

Peer median 1.4% (4 peers)FY2020 1.1%
Stock pay by fiscal yearFY2019FY2025
It depends

Shareholder payout

72.6%
Dividends + buybacks$13.3bn$18.3bnNet income=72.6%

How much of the year's profit was handed back to owners.

👉 Merck paid out 72.6% ✓ of FY2025 profit as dividends and buybacks, below the 97.1% ✓ peer median.

📏 Rule of thumb: Above 100% means it returned more than it earned, using cash savings or debt.

Peer median 97.1% (4 peers)FY2020 106.1%
Shareholder payout by fiscal yearFY2019FY2025

Ratios use fiscal-year-end balance sheet values. Inputs are shown rounded, so dividing them can differ from the result in the last digit. A peer median leaves out peers that do not report the inputs, or where the ratio means nothing (for example, negative shareholders' equity). Rules of thumb are general guides from QuantVantage.ai, not hard limits. No share-price ratios (like price-to-earnings) are shown on this page.

🥊Who are Merck's competitors?

Merck meets other big drug makers product by product. Pfizer sells rival pneumococcal vaccines, Eli Lilly rival diabetes medicines and Johnson & Johnson rival medicines for pulmonary arterial hypertension 41817141516. AbbVie, like Merck, sells cancer medicines 413.

Peer map: growth vs profitability, bubble size = revenue-15%-10%-5%0%5%10%15%20%25%30%35%0%10%20%30%40%Sales growth per year, 3 years →Operating margin →Johnson & Johnson: revenue $94.2bn, growth 5.6%/yr, operating margin 26.8%JNJEli Lilly: revenue $65.2bn, growth 31.7%/yr, operating margin 40.4%LLYMerck: revenue $65.0bn, growth 3.1%/yr, operating margin 34.2%MRKPfizer: revenue $62.6bn, growth -14.8%/yr, operating margin 26.1%PFEAbbVie: revenue $61.2bn, growth 1.8%/yr, operating margin 24.6%ABBV
Peer map: growth vs profitability, bubble size = revenue-15%-10%-5%0%5%10%15%20%25%30%35%0%10%20%30%40%Sales growth per year, 3 years →Operating margin →Johnson & Johnson: revenue $94.2bn, growth 5.6%/yr, operating margin 26.8%JNJEli Lilly: revenue $65.2bn, growth 31.7%/yr, operating margin 40.4%LLYMerck: revenue $65.0bn, growth 3.1%/yr, operating margin 34.2%MRKPfizer: revenue $62.6bn, growth -14.8%/yr, operating margin 26.1%PFEAbbVie: revenue $61.2bn, growth 1.8%/yr, operating margin 24.6%ABBV
Peer map from each company's latest 10-K. Bubble size = revenue. Source: SEC filings [8] [11] [12] [9] [10].
CompanyWhere they competeRevenueGrowth/yr (3y)Op. marginFCF margin
Merck (MRK, FY2025)Cancer medicines, vaccines, other medicines for people, and animal health$65.0bn3.1%34.2%19.0%
AbbVie (ABBV, FY2025)Cancer medicines: both sell them. AbbVie's include Imbruvica, Venclexta, Elahere and Epkinly; Merck's include Keytruda 413$61.2bn1.8%24.6%29.1%
Johnson & Johnson (JNJ, FY2025)Pulmonary arterial hypertension: Johnson & Johnson's Opsumit and Opsynvi against Merck's Winrevair 141516$94.2bn5.6%26.8%20.9%
Eli Lilly (LLY, FY2025)Type 2 diabetes medicines: Lilly's Mounjaro against Merck's Januvia and Janumet 417$65.2bn31.7%40.4%13.8%
Pfizer (PFE, FY2025)Pneumococcal vaccines: Pfizer's Prevnar family against Merck's Vaxneuvance and Capvaxive 418$62.6bn-14.8%26.1%14.5%

Merck says its markets are highly competitive and highly regulated 21. Its rivals include global drug companies, smaller research companies, makers of generic copies and animal health companies 21. Amgen is developing ABP 234, a candidate copy of Keytruda that met its main goals in a comparison study in September 2026 353637.

🧭Merck SWOT: strengths, weaknesses, opportunities and threats

💪 Strengths

  • Keytruda is approved for over 45 uses in the US, across 19 tumor types 6.
  • Over the last three years combined, Merck turned 20.9% ✓ of sales into free cash flow, an A ✓.
  • Winrevair sales grew to $1,443 million in 2025, from $419 million in 2024 43.
  • Merck is the only US maker of ProQuad, a combined measles, mumps, rubella and chickenpox vaccine, and of a chickenpox vaccine, Varivax 6.

🩹 Weaknesses

  • Keytruda made up 49% of Merck's total 2025 sales, so one medicine drives much of the business 45.
  • Gardasil and Gardasil 9 sales fell to $5,233 million in 2025, from $8,583 million in 2024 43.
  • In the third quarter of 2026, Januvia and Janumet sales fell 39% and Bridion sales fell 67%, after generic copies arrived in the US 20.
  • At 30 June 2026, Merck had $53.9bn ✓ of borrowings against $8.4bn ✓ of cash and investments.

🚀 Opportunities

  • In July 2026, the FDA approved Lipfendra, a pill that lowers LDL cholesterol in adults with high cholesterol 6. Merck says it is the first FDA-approved PCSK9 inhibitor pill shown to do so 6.
  • Merck and Moderna tested intismeran with Keytruda after melanoma surgery 26. In October 2026 they reported it cut the risk of the cancer returning, or death, by 42% against Keytruda alone 26.
  • In January 2026, Merck bought Cidara Therapeutics for $9.2 billion; its lead candidate is a long-acting flu-prevention drug in a Phase 3 trial 27.
  • Merck lists 2043 as the key US patent expiry year for Keytruda Qlex, the under-the-skin version 7.

⚠️ Threats

  • Merck expects copies of Keytruda to hurt its sales materially in 2028 and 2029, and they could start in December 2028 5.
  • Merck expects Keytruda to be picked in 2027 for a government-set Medicare price from 1 January 2029, and US Keytruda sales to fall materially after that 21.
  • In patent disputes with Halozyme, temporary court orders (preliminary injunctions) stop sales of Keytruda SC in Denmark and Italy 286. They also block its launch in Germany, the Netherlands, Belgium, Ireland and France 286.
  • Merck says new drugs from rivals can lead to price cuts and replace its products, even when those products have patents 21.

🏰Does Merck have a moat?

Narrow moatPatents and data protection cover Keytruda and newer medicines such as Winrevair, but Keytruda's key US patent ends in 2028 7.
Brand 3/5
Why 3?

Merck sells all its important products under trademarks it considers, together, of material importance 7. It is known as MSD outside the US and Canada and says it has developed medicines and vaccines for more than 130 years 19. Keytruda is approved for over 45 uses in the US 6.

Switching costs 3/5
Why 3?

Keytruda grew in the third quarter of 2026 mainly from use in earlier-stage cancers, plus higher demand in cancers that have spread 20. It is approved for over 45 uses in the US 6. But Merck says new rival drugs can replace its products, even ones with patents 21.

Network effects 1/5
Why 1?

Merck describes its markets as highly competitive, with rivals from global drug companies to makers of generic copies 21.

Cost advantages and scale 3/5
Why 3?

About 24,700 people worked in Merck's research at the end of 2025 22. Merck had about 75,000 staff in all 23. In 2025 it earned $1.5 billion of royalties on its patents and know-how and paid $1.9 billion in royalties to others 7. McKesson, Cencora and Cardinal Health accounted for about 22%, 21% and 13% of what customers owed Merck at the end of 2025 24.

Intangibles (patents, licences, regulation) 4/5
Why 4?

Merck says its patents, taken together, are of material importance in the US and most big foreign markets 7. Key US patents run to 2028 for Keytruda and Gardasil, 2035 for Welireg (with an extension pending) and 2043 for Keytruda Qlex 7. Winrevair has US data protection until 2036 7. Keytruda's patent protection in Europe is expected to end in 2031 5. Merck says losing a patent usually brings a big, fast drop in a product's sales 5. Merck expects copies of Keytruda to hurt sales materially in 2028 and 2029 5.

A moat is what keeps rivals from taking a company's customers and profits. Scores are QuantVantage.ai's judgement (5 = strongest), set with the same rubric on every explainer (orange is Merck; grey dots are peers).

🔭What should you watch next?

Scheduled for 30 November 2026

UK patent trial with Halozyme

A UK trial on whether a Halozyme patent is valid and has been infringed is scheduled to begin on 30 November 2026 28.

October to December 2026

Payment from Blackstone

Blackstone Life Sciences is due to pay Merck $700 million in the fourth quarter of 2026, to fund part of the development costs of sac-TMT 27.

Year to December 2026

Full-year 2026 sales

As of 29 October 2026, Merck expected 2026 sales of $66.8 billion to $67.3 billion 26.

From 1 January 2027

Lower royalty on pneumococcal vaccines

Merck's royalty rate under its main licences for Vaxneuvance and Capvaxive falls from 7.25% of net sales through 2026 to 2.5% from 2027 through 2035 38.

1 January 2027

Government-set Medicare price for Janumet

A Medicare price set under the Inflation Reduction Act takes effect for Janumet and Janumet XR on 1 January 2027 21.

During 2027

Gardasil in the US

Merck expects most of the boost to US Gardasil sales from public-sector buying patterns to unwind in 2027 6.

22 March and 22 April 2027

FDA decisions on Enflonsia and Idvynso

The FDA set 22 March 2027 as its target date for wider use of the RSV medicine Enflonsia, to protect children under 2 at higher risk through their second RSV season 26. It set 22 April 2027 for two applications for the HIV medicine Idvynso 26.

15 June 2027

FDA decision on sac-TMT

The FDA is reviewing sac-TMT for endometrial cancer already treated before, under priority review, with a target date of 15 June 2027 26.

From December 2028

Keytruda's US patent

Copies of Keytruda could start in December 2028, when its main US compound patent expires 5.

📚Learn the words

Revenue (sales)All the money a company takes in from customers before paying any costs.
Gross marginThe share of each sales dollar left after paying to make the product. Medicines are cheap to make compared with their price, so drug makers often have high gross margins.
Operating profitProfit from the main business after paying for products, research, marketing and admin, but before interest and tax.
Net incomeThe profit left at the very end, after every cost and tax has been paid.
Free cash flowThe cash a business has left after running itself and buying equipment. It can pay for dividends, buybacks or deals.
ImmunotherapyA treatment that helps the body's own immune system find and attack a disease such as cancer.
PatentA legal right that stops others from copying an invention for a set number of years.
Generic and biosimilarCheaper copies of a medicine that can be sold once its patents and other protections end. A biosimilar copies a medicine made from living cells.
Alliance revenueMerck's share of the profit from a medicine it sells with a partner company: sales minus the cost of making and selling it 4.
Priority reviewA faster FDA review. The target is six months, against ten months for a standard review 22.
Economic moatA lasting advantage, like a strong patent or high switching costs, that keeps rivals from taking a company's customers.
RatioOne number divided by another, such as profit divided by sales. Ratios let you compare companies of very different sizes.

❓Frequently asked questions about Merck

How does Merck make money?

Merck makes most of its money selling medicines and vaccines for people. In FY2025 that segment brought in $58.1bn ✓, and animal health $6.4bn ✓. The cancer medicine Keytruda alone made up 49% of total 2025 sales 45.

What is Keytruda?

Keytruda is a cancer medicine that helps the immune system attack tumors; it is given into a vein 3. It is approved for over 45 uses in the US 6. A version given as a shot under the skin, Keytruda Qlex, was first approved by the FDA in September 2025 36.

What happens when Keytruda's patent runs out?

Merck expects copies of Keytruda to hurt its sales materially in 2028 and 2029 5. Those copies could start in December 2028, when its main US compound patent expires 5. Merck expects to lose its sole right to sell Keytruda in Europe in 2031 5. Merck says losing a patent usually brings a big, fast drop in a product's sales 5.

Is Merck the same company as MSD?

Yes. Merck is known as MSD outside the United States and Canada 19.

Is Merck still growing?

Merck is still growing, but slowly. Sales rose 1.3% ✓ in FY2025 and 4.6% ✓ in the four quarters to 30 June 2026. From FY2019 to FY2025, growth averaged 8.8% ✓ a year.

Who runs Merck?

Robert M. Davis runs Merck. He became CEO in July 2021 and also chairman in December 2022, after serving as chief financial officer from April 2016 30.

Does Merck make medicines for animals?

Yes, through its Animal Health segment, which brought in $6.4bn ✓ in FY2025. It sells medicines and vaccines for farm animals and pets, including the flea and tick brand Bravecto 13.

How much does Merck spend on research?

Merck spent $15.8bn ✓ on research and development in FY2025. That was 24.3% ✓ of sales, well above the 16.1% ✓ peer median.

🎮Play: higher or lower, then test yourself

Higher or lower · round 1 of 6

Figures come from each company's latest annual report (10-K); fiscal years end in different months. Sources: [8] [11] [12] [9] [10].

Score: 0

🧠 Test yourself

5 quick questions. Score: 0 / 5

1. About how much of Merck's 2025 sales came from Keytruda?

Keytruda made up 49% of Merck's total 2025 sales 45.

2. What does Merck's Bravecto do?

Bravecto is Merck's line of flea and tick products for dogs and cats 3.

3. When was the first Merck Manual published?

The first Merck Manual was published by Merck & Co. in 1899 31.

4. Which disease has Merck's donated medicine Mectizan helped to fight since 1987?

In 1987 Merck promised to donate Mectizan, as much as needed for as long as needed, to help end river blindness 32.

5. Out of every $100 of FY2025 sales, about how much did Merck spend on research?

Merck spent about $24 ✓ of every $100 of sales on research and development.

🔎Sources and method

Every figure comes from a source listed here or is calculated from those sources (marked ✓). Company financials come from the reports each company files with the SEC (10-K annual and 10-Q quarterly reports). Peer grades rank the same measures across the company and its peers. This page contains no share-price data and no valuation.

  1. Merck & Co. Form 10-K for fiscal year 2025 — Cover and Item 1 overview: fiscal year end, state of incorporation, segments, products, customers (accessed 2026-11-04)
  2. Merck (MRK) Form 10-K for fiscal year 2025, filed 2026-02-24 — revenue and cost of sales by product, segment and geography (accessed 2026-11-04)
  3. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 product descriptions: Keytruda, Keytruda Qlex, vaccines, hospital, cardiometabolic and Animal Health products (accessed 2026-11-04)
  4. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 product sales table: 2025, 2024 and 2023 sales by segment and top product (accessed 2026-11-04)
  5. Merck & Co. Form 10-K for fiscal year 2025 — Item 1A risk factors: product concentration, loss of exclusivity timing, Gardasil in China (accessed 2026-11-04)
  6. Merck & Co. Form 10-Q for the quarter ended September 30, 2026 — MD&A: Keytruda and Keytruda SC, Gardasil, U.S. vaccine policy, ProQuad and Varivax, Lipfendra, MFN and Medicaid, Animal Health (accessed 2026-11-04)
  7. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 patents, trademarks and licenses: key patent expiry table, footnotes, data exclusivity, royalties (accessed 2026-11-04)
  8. SEC EDGAR companyfacts: Merck (MRK) — annual 10-K facts (accessed 2026-11-04)
  9. SEC EDGAR companyfacts: ELI LILLY & Co (LLY) — annual 10-K facts (accessed 2026-11-04)
  10. SEC EDGAR companyfacts: PFIZER INC (PFE) — annual 10-K facts (accessed 2026-11-04)
  11. SEC EDGAR companyfacts: AbbVie Inc. (ABBV) — annual 10-K facts (accessed 2026-11-04)
  12. SEC EDGAR companyfacts: JOHNSON & JOHNSON (JNJ) — annual 10-K facts (accessed 2026-11-04)
  13. AbbVie Form 10-K for fiscal year 2025 — Item 1 oncology products and MD&A net revenues: Imbruvica, Venclexta, Elahere, Epkinly 2025 (accessed 2026-11-04)
  14. Johnson & Johnson Form 10-K for fiscal year 2025 — Item 1 Innovative Medicine segment: therapeutic areas, customers, key products (accessed 2026-11-04)
  15. Johnson & Johnson Form 10-K for fiscal year 2025 — Item 7 MD&A: 2025 sales by region and product, STELARA biosimilar impact, franchise drivers, research and development expense (accessed 2026-11-04)
  16. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 Winrevair description and 2025 product sales table (accessed 2026-11-04)
  17. Eli Lilly Form 10-K for fiscal year 2025 — MD&A revenue by product: Mounjaro 2025 revenue (accessed 2026-11-04)
  18. Pfizer Form 10-K for fiscal year 2025 — MD&A product revenues: Prevnar family 2025 worldwide revenues (accessed 2026-11-04)
  19. Merck & Co. third-quarter 2026 results release (Form 8-K exhibit 99.1, October 29, 2026) — About our company: known as MSD outside the U.S. and Canada; more than 130 years (accessed 2026-11-04)
  20. Merck & Co. third-quarter 2026 results release (Form 8-K exhibit 99.1, October 29, 2026) — Third-quarter 2026 sales, product sales and earnings per share (accessed 2026-11-04)
  21. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 competition and health care environment: competition, MFN agreement, IRA price setting, China (accessed 2026-11-04)
  22. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 research and development: research headcount, pipeline areas, FDA review process and priority vouchers (accessed 2026-11-04)
  23. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 human capital: employees at December 31, 2025 (accessed 2026-11-04)
  24. Merck & Co. Form 10-K for fiscal year 2025 — Note on concentrations of credit risk: largest wholesaler customers (accessed 2026-11-04)
  25. SEC EDGAR companyfacts: Merck (MRK) — balance sheet at 2026-06-30 (accessed 2026-11-04)
  26. Merck & Co. third-quarter 2026 results release (Form 8-K exhibit 99.1, October 29, 2026) — Third-quarter 2026 pipeline highlights, FDA action dates and full-year 2026 outlook (accessed 2026-11-04)
  27. Merck & Co. Form 10-Q for the quarter ended September 30, 2026 — Note 2 acquisitions, collaborations and funding: Cidara, Terns, TARGAN, SciBrunch, Blackstone (accessed 2026-11-04)
  28. Merck & Co. Form 10-Q for the quarter ended September 30, 2026 — Note 8 contingencies: subcutaneous pembrolizumab patent matters with Halozyme; securities class action (accessed 2026-11-04)
  29. SEC EDGAR companyfacts: Merck (MRK) — quarterly 10-Q/10-K facts (accessed 2026-11-04)
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  31. Merck Manuals: history of the Merck Manuals — First Merck Manual, 1899 (accessed 2026-11-04)
  32. Merck story: the Mectizan Donation Program — Mectizan donation start year, diseases and treatments donated (accessed 2026-11-04)
  33. Merck & Co. Form 10-K for fiscal year 2025 — Item 2 properties: headquarters and research sites (accessed 2026-11-04)
  34. Merck & Co. Form 10-K for fiscal year 2025 — Item 1 operations outside the U.S.: share of sales by subsidiaries outside the U.S. (accessed 2026-11-04)
  35. Amgen Inc. Form 10-K for fiscal year 2025 — Item 1 competition: biosimilars, generics, own biosimilar launches, competitor table (accessed 2026-11-04)
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